Selective inhibition of cancer cells by enzyme-induced gain of function of phosphorylated melittin analogues† †Electronic supplementary information (ESI) available: Mass spectra and other materials. See DOI: 10.1039/c7sc03217j

Highly selective acylation of polyamines and aminoglycosides by 5-acyl-5-phenyl-1,5-dihydro-4H-pyrazol-4-ones† †Electronic supplementary information (ESI) available: Experimental procedures, kinetic data, UV/Vis spectra, NMR spectra, and HPLC traces. X-ray data for 44. CCDC 1563600. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c7sc03184j Click here for additional data file. Click here for additional data file.

First synthetic analogues of diphosphoinositol polyphosphates: interaction with PP-InsP5 kinase† †Electronic supplementary information (ESI) available: Data deposition: the atomic coordinates and structure factors have been deposited in the Protein Data Bank, www.pdb.org (PDB ID code 4GB4). See DOI: 10.1039/c2cc36044f Click here for additional data file.

We synthesised analogues of diphosphoinositol polyphosphates (PP-InsPs) in which the diphosphate is replaced by an α-phosphonoacetic acid (PA) ester. Structural analysis revealed that 5-PA-InsP(5) mimics 5-PP-InsP(5) binding to the kinase domain of PPIP5K2; both molecules were phosphorylated by the enzyme. PA-InsPs are promising candidates for further studies into the biology of PP-InsPs.

The protecting-group free selective 3′-functionalization of nucleosides† †Electronic supplementary information (ESI) available. CCDC 1525736–1525737. For ESI and crystallographic data in CIF or other electronic format see DOI: 10.1039/c6sc05081f Click here for additional data file. Click here for additional data file.

General ............................................................................................................................................S1 General Procedure A: Preparation of 3’-Phosphorylated Nucleosides .................................S1 Preparation of 3’-acetylated Nucleosides...................................................................................S8 NMR Studies .........

Structural characterization of holo- and apo-myoglobin in the gas phase by ultraviolet photodissociation mass spectrometry† †Electronic supplementary information (ESI) available: ESI mass spectra of holo- and apo-myoglobin, schematic representation of holo-myoglobin, histograms of HCD and UVPD fragmentation yields of apo-myoglobin, B-factors and solvent accessibilities. See DOI: 10.1039/c4sc03200d Click here for additional data file.

Selective anomeric acetylation of unprotected sugars in water† †Electronic supplementary information (ESI) available: Experimental details for the synthesis of all compounds and spectra. See DOI: 10.1039/c6sc04667c Click here for additional data file.